A better understanding of the molecular mechanisms that enable CO2 control of stomatal movements could aid in future molecular enhanced breeding-, engineering-, and/or gene editing-driven improvement of stomatal WUE traits that are better adapted to diverse environments in a high CO2 and climate change-challenged world. In recent years, advances have been made toward understanding the molecular mechanisms that cause CO2-regulated stomatal movements, with some key questions remaining to be resolved as highlighted here.
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